Publications of Martin Gotthardt

Accepted or to appear

Papers in international journals

  1. S. Lütje, B. Gomez, J. Cohnen, L. Umutlu, M. Gotthardt, T. Poeppel, A. Bockisch and S. Rosenbaum-Krumme. "Imaging of Prostate-Specific Membrane Antigen Expression in Metastatic Differentiated Thyroid Cancer Using 68Ga-HBED-CC-PSMA PET/CT". Abstract DOI PMID

  2. I. van der Kroon, W. der Woliner-van Weg, M. Brom, L. Joosten, C. Frielink, M. Konijnenberg, E. Visser and M. Gotthardt. "Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.". Abstract DOI PMID


2018

Papers in international journals

  1. V. Christmann, M. van der Putten, L. Rodwell, K. Steiner, M. Gotthardt, J. van Goudoever and A. van Heijst. "Effect of early nutritional intake on long-term growth and bone mineralization of former very low birth weight infants.", 2018. Abstract DOI PMID

  2. S. Demine, A. Balhuizen, V. Debaille, L. Joosten, M. Fereau, S. Chilla, I. Millard, R. Scharfmann, D. Egrise, S. Goldman, P. Marchetti, M. Gotthardt, S. Laurent, C. Burtea and D. Eizirik. "Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.", 2018. Abstract DOI PMID

  3. D. Evers, B. Bär, M. Gotthardt and W. van der Velden. "Activity of decitabine in pericardial myeloid sarcoma.", 2018. DOI PMID

  4. M. Gotthardt, D. Eizirik, H. Aanstoot, O. Korsgren, D. Mul, F. Martin, M. Boss, T. Jansen, S. van Lith, M. Buitinga, O. Eriksson, M. Cnop and M. Brom. "Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.", 2018. Abstract DOI PMID

  5. L. Joosten, M. Brom, H. Peeters, S. Heskamp, M. Béhé, O. Boerman and M. Gotthardt. "Enhanced Specific Activity by Multichelation of Exendin-3 Leads To Improved Image Quality and In Vivo Beta Cell Imaging.", 2018. Abstract DOI PMID

  6. C. Lageweg, M. van der Putten, J. van Goudoever, T. Feuth, M. Gotthardt, A. van Heijst and V. Christmann. "Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry.", 2018. Abstract DOI PMID

  7. S. Willekens, L. Joosten, O. Boerman, M. Brom and M. Gotthardt. "Characterization of , javax.xml.bind.JAXBElement@5e6ff189, In-labeled Glucose-Dependent Insulinotropic Polypeptide as a Radiotracer for Neuroendocrine Tumors.", 2018. Abstract DOI PMID


2017

Papers in international journals

  1. L. Joosten, M. Brom, M. Schäfer, O. Boerman, E. Weihe and M. Gotthardt. "Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.", 2017. Abstract DOI PMID

  2. S. Willekens, I. van der Kroon, D. Bos, L. Joosten, C. Frielink, O. Boerman, M. Brom and M. Gotthardt. "Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [ (123) I]IBZM.", 2017. Abstract DOI PMID


2016

Papers in international journals

  1. I. van der Kroon, K. Andralojc, S. Willekens, D. Bos, L. Joosten, O. Boerman, M. Brom and M. Gotthardt. "Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT.", 2016. Abstract/PDF DOI PMID

  2. W. der Woliner-van Weg, L. Deden, A. Meeuwis, M. Koenrades, L. Peeters, H. Kuipers, G. Laanstra, M. Gotthardt, C. Slump and E. Visser. "A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using (111)In-exendin.", 2016. Abstract DOI PMID

  3. R. Bertrand, A. Wolf, Y. Ivashchenko, M. Löhn, M. Schäfer, M. Brönstrup, M. Gotthardt, V. Derdau and O. Plettenburg. "Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting Fluorescent Probe for ?-Cell Imaging.", 2016. Abstract DOI PMID

  4. I. van der Kroon, L. Joosten, B. Nock, T. Maina, O. Boerman, M. Brom and M. Gotthardt. "Improved Quantification of the Beta Cell Mass after Pancreas Visualization with (99m)Tc-demobesin-4 and Beta Cell Imaging with (111)In-exendin-3 in Rodents.", 2016. Abstract PMID

  5. D. Bailey, B. Pichler, B. Gückel, H. Barthel, A. Beer, R. Botnar, R. Gillies, V. Goh, M. Gotthardt, R. Hicks, R. Lanzenberger, C. la Fougere, M. Lentschig, S. Nekolla, T. Niederdraenk, K. Nikolaou, J. Nuyts, D. Olego, K. Riklund, A. Signore, M. Schäfers, V. Sossi, M. Suminski, P. Veit-Haibach, L. Umutlu, M. Wissmeyer and T. Beyer. "Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; T"ubingen, Germany", 2016. Abstract DOI PMID

  6. M. Brom, G. Franssen, L. Joosten, M. Gotthardt and O. Boerman. "The effect of purification of Ga-68-labeled exendin on in vivo distribution.", 2016. Abstract DOI PMID

  7. R. Bertrand, I. Hamp, M. Brönstrup, R. Weck, M. Lukacevic, A. Polyak, T. Ross, M. Gotthardt, O. Plettenburg and V. Derdau. "Synthesis of GPR40 targeting (3) H- and (18) F-probes towards selective beta cell imaging.", 2016. Abstract/PDF DOI PMID

  8. T. Puar, A. van Berkel, M. Gotthardt, B. Havekes, A. Hermus, J. Lenders, W. vanMarken Lichtenbelt, Y. Xu, B. Brans and H. Timmers. "Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma.", 2016. Abstract DOI PMID

  9. O. Eriksson, M. Laughlin, M. Brom, P. Nuutila, M. Roden, A. Hwa, R. Bonadonna and M. Gotthardt. "In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use.", 2016. Abstract/PDF DOI PMID

  10. S. Willekens, I. van der Kroon, L. Joosten, C. Frielink, O. Boerman, S. van den Broek, M. Brom and M. Gotthardt. "SPECT of Transplanted Islets of Langerhans by Dopamine 2 Receptor Targeting in a Rat Model.", 2016. Abstract DOI PMID

  11. S. Willekens, L. Joosten, O. Boerman, A. Balhuizen, D. Eizirik, M. Gotthardt and M. Brom. "Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.", 2016. Abstract DOI PMID

  12. W. Eter, S. Parween, L. Joosten, C. Frielink, M. Eriksson, M. Brom, U. Ahlgren and M. Gotthardt. "SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments.", 2016. Abstract DOI PMID


2015

Papers in international journals

  1. S. Lütje, S. Heskamp, A. Cornelissen, T. Poeppel, S. van den Broek, S. Rosenbaum-Krumme, A. Bockisch, M. Gotthardt, M. Rijpkema and O. Boerman. "PSMA Ligands for Radionuclide Imaging and Therapy of Prostate Cancer: Clinical Status", 2015.

  2. W. Grootjans, A. Meeuwis, C. Slump, L. de Geus-Oei, M. Gotthardt and E. Visser. "Performance of 3DOSEM and MAP algorithms for reconstructing low count SPECT acquisitions.", 2015. Abstract DOI PMID

  3. A. van Berkel, J. Rao, J. Lenders, N. Pellegata, B. Kusters, I. Piscaer, A. Hermus, T. Plantinga, J. Langenhuijsen, D. Vriens, M. Janssen, M. Gotthardt and H. Timmers. "Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters.", 2015. Abstract DOI PMID

  4. W. Eter, D. Bos, C. Frielink, O. Boerman, M. Brom and M. Gotthardt. "Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.", 2015. Abstract DOI PMID

  5. T. Puar, A. van Berkel, M. Gotthardt, B. Havekes, A. Hermus, J. Lenders, W. vanMarken Lichtenbelt, Y. Xu, B. Brans and H. Timmers. "Genotype-dependent Brown Adipose Tissue Activation in Patients with Pheochromocytoma and Paraganglioma.", 2015. Abstract DOI PMID

  6. W. der Woliner-van Weg, R. Schoffelen, R. Hobbs, M. Gotthardt, D. Goldenberg, R. Sharkey, C. Slump, W. van der Graaf, W. Oyen, O. Boerman and others. "Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy", 2015.

  7. M. Brom, L. Joosten, C. Frielink, O. Boerman and M. Gotthardt. "111In-exendin uptake in the pancreas correlates with the beta cell mass and not with the alpha cell mass", 2015. Abstract/PDF DOI PMID


2014

Papers in international journals

  1. C. Chauveau, C. Bonnemann, C. Julien, A. Kho, H. Marks, B. Talim, P. Maury, M. Arne-Bes, E. Uro-Coste, A. Alexandrovich, A. Vihola, S. Schafer, B. Kaufmann, L. Medne, N. Hübner, A. Foley, M. Santi, B. Udd, H. Topaloglu, S. Moore, M. Gotthardt, M. Samuels, M. Gautel and A. Ferreiro. "Recessive TTN truncating mutations define novel forms of core myopathy with heart disease", 2014. Abstract/PDF DOI PMID

  2. F. Elhamine, M. Radke, G. Pfitzer, H. Granzier, M. Gotthardt and R. Stehle. "Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics", 2014. Abstract/PDF DOI PMID

  3. F. Freiberg, M. Sauter, S. Pinkert, T. Govindarajan, J. Kaldrack, M. Thakkar, H. Fechner, K. Klingel and M. Gotthardt. "Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor", 2014. Abstract DOI PMID

  4. H. Maatz, M. Jens, M. Liss, S. Schafer, M. Heinig, M. Kirchner, E. Adami, C. Rintisch, V. Dauksaite, M. Radke, M. Selbach, P. Barton, S. Cook, N. Rajewsky, M. Gotthardt, M. Landthaler and N. Hubner. "RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing", 2014. Abstract/PDF DOI PMID

  5. R. Marsman, C. Bezzina, F. Freiberg, A. Verkerk, M. Adriaens, S. Podliesna, C. Chen, B. Purfürst, B. Spallek, T. Koopmann, I. Baczko, C. Dos Remedios, A. George Jr, N. Bishopric, E. Lodder, J. de Bakker, R. Fischer, R. Coronel, A. Wilde, M. Gotthardt and C. Remme. "Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia", 2014. Abstract/PDF DOI PMID

  6. K. Mikkola, M. Kirsi, C. Yim, Y. Cheng-Bin, V. Fagerholm, F. Veronica, T. Ishizu, I. Tamiko, V. Elomaa, E. Viki-Veikko, J. Rajander, R. Johan, J. Jurttila, J. Jori, T. Saanijoki, S. Tiina, T. Tolvanen, T. Tuula, M. Tirri, T. Marko, E. Gourni, G. Eleni, M. Béhé, B. Martin, M. Gotthardt, G. Martin, J. Reubi, R. Claude, H. Mäcke, M. Helmut, A. Roivainen, R. Anne, O. Solin, S. Olof, P. Nuutila and N. Pirjo. "64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats", 2014. Abstract/PDF DOI PMID

  7. W. Grootjans, L. de Geus-Oei, A. Meeuwis, C. van der Vos, M. Gotthardt, W. Oyen and E. Visser. "Amplitude-based optimal respiratory gating in positron emission tomography in patients with primary lung cancer", 2014. Abstract/PDF DOI PMID

  8. M. Gotthardt, D. Eizirik, M. Cnop and M. Brom. "Beta cell imaging - a key tool in optimized diabetes prevention and treatment", 2014. Abstract/PDF DOI PMID

  9. A. van Berkel, J. Rao, B. Kusters, T. Demir, E. Visser, A. Mensenkamp, J. van der Laak, E. Oosterwijk, J. Lenders, F. Sweep, R. Wevers, A. Hermus, J. Langenhuijsen, D. Kunst, K. Pacak, M. Gotthardt and H. Timmers. "Correlation Between In Vivo 18F-FDG PET and Immunohistochemical Markers of Glucose Uptake and Metabolism in Pheochromocytoma and Paraganglioma", 2014. Abstract/PDF DOI PMID

  10. M. Brom, O. Boerman, M. Gotthardt and W. Oyen. "Preclinical Studies of SPECT and PET Tracers for NET", 2014. Abstract DOI PMID

  11. M. Brom, W. der Woliner-van Weg, L. Joosten, C. Frielink, T. Bouckenooghe, P. Rijken, K. Andralojc, B. Göke, M. de Jong, D. Eizirik, M. Béhé, T. Lahoutte, W. Oyen, C. Tack, M. Janssen, O. Boerman and M. Gotthardt. "Non-invasive quantification of the beta cell mass by SPECT with (111)In-labelled exendin", 2014. Abstract/PDF DOI PMID

  12. L. Freudenberg, D. Hellwig, F. Mottaghy, C. Franzius and M. Gotthardt. "Nuclear medicine training and practice in Germany", 2014. PDF DOI PMID

  13. R. van Hoorn, D. Vriens, J. Postema, A. Arens, A. Pfestroff, W. Oyen and M. Gotthardt. "The influence of SPECT reconstruction algorithms on image quality and diagnostic accuracy in phantom measurements and 99mTc-sestamibi parathyroid scintigraphy", 2014. Abstract DOI PMID


2013

Papers in international journals

  1. A. Bhunia, M. Gotthardt, M. Yadav, M. Gamer, A. Eichhöfer, W. Kleist and P. Roesky. "Salen-based coordination polymers of manganese and the rare-earth elements: synthesis and catalytic aerobic epoxidation of olefins", 2013. Abstract DOI PMID

  2. W. van der Bruggen, A. Arens, M. van der Drift, L. de Geus-Oei, M. Gotthardt and W. Oyen. "Referred shoulder pain in a patient with small cell lung cancer. Adrenal gland metastases", 2013. PMID

  3. K. Freriks, T. Sas, M. Traas, R. Netea-Maier, M. den Heijer, A. Hermus, J. Wit, J. van der Alfen-van Velden, B. Otten, S. de Muinck Keizer-Schrama, M. Gotthardt, P. Dejonckere, G. Zandwijken, L. Menke and H. Timmers. "Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome", 2013. Abstract DOI PMID

  4. L. de Geus-Oei, A. Mavinkurve-Groothuis, L. Bellersen, M. Gotthardt, W. Oyen, L. Kapusta and H. van Laarhoven. "Scintigraphic techniques for early detection of cancer treatment-induced cardiotoxicity", 2013. Abstract/PDF DOI PMID

  5. M. Gotthardt, C. Bleeker-Rovers, O. Boerman and W. Oyen. "Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques", 2013. Abstract DOI PMID

  6. M. Gotthardt, L. de Geus-Oei and A. Arens. "Nodular fasciitis on (18)F-FDG PET", 2013. DOI PMID

  7. B. Schreier, S. Rabe, B. Schneider, M. Bretschneider, S. Rupp, S. Ruhs, J. Neumann, U. Rueckschloss, M. Sibilia, M. Gotthardt, C. Grossmann and M. Gekle. "Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy", 2013. Abstract DOI PMID

  8. F. van de Watering, P. Laverman, V. Cuijpers, M. Gotthardt, E. Bronkhorst, O. Boerman, J. Jansen and J. van den Beucken. "The biological performance of injectable calcium phosphate/PLGA cement in osteoporotic rats", 2013. Abstract DOI PMID


2012

Papers in international journals

  1. K. Andralojc, M. Srinivas, M. Brom, L. Joosten, I. de Vries, D. Eizirik, O. Boerman, P. Meda and M. Gotthardt. "Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis", 2012. Abstract/PDF DOI PMID

  2. T. Blokhuis, P. Buma, N. Verdonschot, M. Gotthardt and T. Hendriks. "BMP-7 stimulates early diaphyseal fracture healing in estrogen deficient rats", 2012. Abstract DOI PMID

  3. O. Boerman and M. Gotthardt. "18F-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster?", 2012. PDF DOI PMID

  4. M. Brom, L. Joosten, W. Oyen, M. Gotthardt and O. Boerman. "Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer", 2012. Abstract/PDF DOI PMID

  5. M. Brom, L. Joosten, W. Oyen, M. Gotthardt and O. Boerman. "Radiolabelled GLP-1 analogues for in vivo targeting of insulinomas", 2012. Abstract DOI PMID

  6. W. Guo, S. Schafer, M. Greaser, M. Radke, M. Liss, T. Govindarajan, H. Maatz, H. Schulz, S. Li, A. Parrish, V. Dauksaite, P. Vakeel, S. Klaassen, B. Gerull, L. Thierfelder, V. Regitz-Zagrosek, T. Hacker, K. Saupe, G. Dec, P. Ellinor, C. MacRae, B. Spallek, R. Fischer, A. Perrot, C. Özcelik, K. Saar, N. Hubner and M. Gotthardt. "RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing", 2012. Abstract/PDF DOI PMID

  7. D. Hellwig, L. Freudenberg, F. Mottaghy, C. Franzius, T. Krause, I. Garai, M. Biermann, T. Grüning, T. Leitha and M. Gotthardt. "[Nuclear medicine in Europe: education]", 2012. Abstract DOI PMID

  8. H. Theunisse, M. Gotthardt and E. Mylanus. "Surgical planning and evaluation of implanting a penetrating cochlear nerve implant in human temporal bones using microcomputed tomography", 2012. Abstract DOI PMID

  9. G. de Jong, T. Hendriks, R. Bleichrodt, H. Dekker, R. Mus, M. Gotthardt, E. Visser, W. Oyen and O. Boerman. "(18)F-2-deoxy-2-fluoro-D-glucose positron emission tomography, computed tomography, and magnetic resonance imaging for the detection of experimental colorectal liver metastases", 2012. Abstract PMID


2011

Papers in international journals

  1. E. Vegt, M. Melis, A. Eek, M. de Visser, M. Brom, W. Oyen, M. Gotthardt, M. de Jong and O. Boerman. "Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice", 2011. Abstract/PDF DOI PMID

  2. M. Brom, L. Joosten, P. Laverman, W. Oyen, M. Béhé, M. Gotthardt and O. Boerman. "Preclinical evaluation of 68Ga-DOTA-minigastrin for the detection of cholecystokinin-2/gastrin receptor-positive tumors", 2011. Abstract PMID

  3. C. Chung, M. Methawasin, O. Nelson, M. Radke, C. Hidalgo, M. Gotthardt and H. Granzier. "Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions", 2011. Abstract/PDF DOI PMID

  4. M. Gotthardt. "A therapeutic insight in beta-cell imaging?", 2011. DOI PMID

  5. J. Nedrud, S. Labeit, M. Gotthardt and H. Granzier. "Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle", 2011. Abstract/PDF DOI PMID

  6. B. Schreier, M. Döhler, S. Rabe, B. Schneider, G. Schwerdt, S. Ruhs, M. Sibilia, M. Gotthardt, M. Gekle and C. Grossmann. "Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1", 2011. Abstract DOI PMID

  7. K. da Silva Lopes, A. Pietas, M. Radke and M. Gotthardt. "Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres", 2011. Abstract/PDF DOI PMID


2010

Papers in international journals

  1. U. Ahlgren and M. Gotthardt. "Approaches for imaging islets: recent advances and future prospects", 2010. Abstract DOI PMID

  2. M. Brom, K. Andrałojć, W. Oyen, O. Boerman and M. Gotthardt. "Development of radiotracers for the determination of the beta-cell mass in vivo", 2010. Abstract PMID

  3. M. Brom, W. Oyen, L. Joosten, M. Gotthardt and O. Boerman. "68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET", 2010. Abstract/PDF DOI PMID

  4. W. van der Bruggen, C. Bleeker-Rovers, O. Boerman, M. Gotthardt and W. Oyen. "PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review", 2010. Abstract/PDF DOI PMID

  5. J. Disselhorst, M. Brom, P. Laverman, C. Slump, O. Boerman, W. Oyen, M. Gotthardt and E. Visser. "Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner", 2010. Abstract/PDF DOI PMID

  6. M. Gotthardt. "[Radiogenic nephropathy]", 2010. Abstract PMID

  7. M. Gotthardt. "Beta cell imaging--why we need it and what has been achieved", 2010. PMID

  8. M. Gotthardt, A. Arens, E. van der Heijden, L. de Geus-Oei and W. Oyen. "Nodular fasciitis on F-18 FDG PET", 2010. Abstract DOI PMID

  9. M. Gotthardt, C. Bleeker-Rovers, O. Boerman and W. Oyen. "Imaging of inflammation by PET, conventional scintigraphy, and other imaging techniques", 2010. Abstract/PDF DOI PMID

  10. B. Hudson, C. Hidalgo, M. Gotthardt and H. Granzier. "Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness", 2010. Abstract/PDF DOI PMID

  11. E. Lee, J. Peng, M. Radke, M. Gotthardt and H. Granzier. "Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice", 2010. Abstract/PDF DOI PMID

  12. E. Vegt, A. Eek, W. Oyen, M. de Jong, M. Gotthardt and O. Boerman. "Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides", 2010. Abstract/PDF DOI PMID

  13. E. Vegt, M. de Jong, J. Wetzels, R. Masereeuw, M. Melis, W. Oyen, M. Gotthardt and O. Boerman. "Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention", 2010. Abstract/PDF DOI PMID

  14. D. Vriens, A. Arens, J. de Rooy, B. Schreuder, P. Brons and M. Gotthardt. "Hardware failure: a potential pitfall in assessing recurrent Ewing's sarcoma on bone scintigraphy", 2010. DOI PMID


2009

Papers in international journals

  1. R. Fischer, W. Poller, H. Schultheiss and M. Gotthardt. "CAR-diology--a virus receptor in the healthy and diseased heart", 2009. Abstract/PDF DOI PMID

  2. H. Granzier, M. Radke, J. Peng, D. Westermann, O. Nelson, K. Rost, N. King, Q. Yu, C. Tschöpe, M. McNabb, D. Larson, S. Labeit and M. Gotthardt. "Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction", 2009. Abstract DOI PMID

  3. C. Ottenheijm, C. Hidalgo, K. Rost, M. Gotthardt and H. Granzier. "Altered contractility of skeletal muscle in mice deficient in titin's M-band region", 2009. Abstract/PDF DOI PMID

  4. Y. Shi, C. Chen, U. Lisewski, U. Wrackmeyer, M. Radke, D. Westermann, M. Sauter, C. Tschöpe, W. Poller, K. Klingel and M. Gotthardt. "Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo", 2009. Abstract/PDF DOI PMID

  5. E. Visser, J. Disselhorst, M. Brom, P. Laverman, M. Gotthardt, W. Oyen and O. Boerman. "Spatial resolution and sensitivity of the Inveon small-animal PET scanner", 2009. Abstract/PDF DOI PMID

  6. D. Westermann, A. Riad, U. Richter, S. Jäger, K. Savvatis, M. Schuchardt, N. Bergmann, M. Tölle, D. Nagorsen, M. Gotthardt, H. Schultheiss and C. Tschöpe. "Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure", 2009. Abstract/PDF DOI PMID


2008

Papers in international journals

  1. P. Laverman, S. Roosenburg, M. Gotthardt, J. Park, W. Oyen, M. de Jong, M. Hellmich, F. Rutjes, F. van Delft and O. Boerman. "Targeting of a CCK(2) receptor splice variant with (111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin", 2008. Abstract/PDF DOI PMID

  2. R. Lukowski, P. Weinmeister, D. Bernhard, S. Feil, M. Gotthardt, J. Herz, S. Massberg, A. Zernecke, C. Weber, F. Hofmann and R. Feil. "Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis", 2008. Abstract DOI PMID

  3. K. Raddatz, D. Albrecht, F. Hochgräfe, M. Hecker and M. Gotthardt. "A proteome map of murine heart and skeletal muscle", 2008. Abstract DOI PMID

  4. E. Rolleman, B. Bernard, W. Breeman, F. Forrer, E. de Blois, J. Hoppin, M. Gotthardt, O. Boerman, E. Krenning and M. de Jong. "Molecular imaging of reduced renal uptake of radiolabelled [DOTA0,Tyr3]octreotate by the combination of lysine and Gelofusine in rats", 2008. Abstract PMID

  5. U. Lisewski, Y. Shi, U. Wrackmeyer, R. Fischer, C. Chen, A. Schirdewan, R. Jüttner, F. Rathjen, W. Poller, M. Radke and M. Gotthardt. "The tight junction protein CAR regulates cardiac conduction and cell-cell communication", 2008. Abstract/PDF DOI PMID

  6. E. Vegt, J. van Eerd, A. Eek, W. Oyen, J. Wetzels, M. de Jong, F. Russel, R. Masereeuw, M. Gotthardt and O. Boerman. "Reducing renal uptake of radiolabeled peptides using albumin fragments", 2008. Abstract/PDF DOI PMID


2007

Papers in international journals

  1. M. Béhé, M. Gotthardt and T. Behr. "Imaging of gastrinomas by nuclear medicine methods", 2007. Abstract/PDF DOI PMID

  2. M. Behe, B. Keil, H. Alfke, I. Böhm, A. Kiessling, M. Gotthardt and J. Heverhagen. "[Combination of radiological and nuclear medical imaging in animals: an overview about today's possibilities]", 2007. Abstract DOI PMID

  3. I. Dijkgraaf, O. Boerman, W. Oyen, F. Corstens and M. Gotthardt. "Development and application of peptide-based radiopharmaceuticals", 2007. Abstract PMID

  4. M. Gotthardt, S. Bröker, A. Schlieck, A. Bauhofer, B. Herbst, M. Béhé, F. Corstens, T. Behr and C. Görg. "Scintigraphy with 99mTc-labeled heat-altered erythrocytes in diagnosing hyposplenia: prospective comparison to 99mTc-labeled colloids and colour-coded duplex ultrasonography", 2007. Abstract PMID

  5. M. Gotthardt, J. van Eerd-Vismale, W. Oyen, M. de Jong, H. Zhang, E. Rolleman, H. Maecke, M. Béhé and O. Boerman. "Indication for different mechanisms of kidney uptake of radiolabeled peptides", 2007. Abstract PMID

  6. H. Granzier, M. Radke, J. Royal, Y. Wu, T. Irving, M. Gotthardt and S. Labeit. "Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle", 2007. Abstract/PDF DOI PMID

  7. P. Jansen, K. Giehl, J. Nyengaard, K. Teng, O. Lioubinski, S. Sjoegaard, T. Breiderhoff, M. Gotthardt, F. Lin, A. Eilers, C. Petersen, G. Lewin, B. Hempstead, T. Willnow and A. Nykjaer. "Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury", 2007. Abstract/PDF DOI PMID

  8. M. Kalinowski, K. Goldmann, M. Gotthardt, M. Rössler, A. Pfestroff, K. Klose and H. Wagner. "Effectiveness and renal tolerance of multidetector helical CT with gadobutrol: results of a comparative porcine study", 2007. Abstract/PDF DOI PMID

  9. J. Peng, K. Raddatz, J. Molkentin, Y. Wu, S. Labeit, H. Granzier and M. Gotthardt. "Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region", 2007. Abstract DOI PMID

  10. M. Radke, J. Peng, Y. Wu, M. McNabb, O. Nelson, H. Granzier and M. Gotthardt. "Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy", 2007. Abstract/PDF DOI PMID

  11. A. Wicki, D. Wild, D. Storch, C. Seemayer, M. Gotthardt, M. Behe, S. Kneifel, M. Mihatsch, J. Reubi, H. Mäcke and G. Christofori. "[Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma", 2007. Abstract DOI PMID


2006

Papers in international journals

  1. M. Gotthardt, M. Béhé, D. Beuter, A. Battmann, A. Bauhofer, T. Schurrat, M. Schipper, H. Pollum, W. Oyen and T. Behr. "Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma", 2006. Abstract DOI PMID

  2. M. Gotthardt, M. Béhé, J. Grass, A. Bauhofer, A. Rinke, M. Schipper, M. Kalinowski, R. Arnold, W. Oyen and T. Behr. "Added value of gastrin receptor scintigraphy in comparison to somatostatin receptor scintigraphy in patients with carcinoids and other neuroendocrine tumours", 2006. Abstract DOI PMID

  3. M. Gotthardt, I. Dijkgraaf, O. Boerman and W. Oyen. "Nuclear medicine imaging and therapy of neuroendocrine tumours", 2006. Abstract DOI PMID

  4. M. Gotthardt, G. Lalyko, J. van Eerd-Vismale, B. Keil, T. Schurrat, M. Hower, P. Laverman, T. Behr, O. Boerman, B. Göke and M. Béhé. "A new technique for in vivo imaging of specific GLP-1 binding sites: first results in small rodents", 2006. Abstract DOI PMID

  5. M. Gotthardt, C. Rubner, A. Bauhofer, F. Berce, W. Oyen, J. Goecke, A. Pfestroff, A. Schlieck, F. Corstens, M. Béhé and T. Behr. "What is the best pre-therapeutic dosimetry for successful radioiodine therapy of multifocal autonomy?", 2006. Abstract PMID

  6. M. Gotthardt, M. Siegert, A. Schlieck, S. Schneider, A. Kohnert, M. Gross, C. Schäfer, R. Wagner, S. Hörmann, T. Behr, R. Engenhart-Cabillic, K. Klose, H. Jungclas and U. Glowalla. "How to successfully implement E-learning for both students and teachers", 2006. Abstract PMID

  7. M. Gotthardt, M. Stübinger, J. Pansegrau, B. Buchwald, J. Goecke, A. Pfestroff, F. Corstens and T. Behr. "Decrease of (99m)Tc-uptake in autonomous thyroid tissue in Germany since the 1970s. Clinical implications for radioiodine therapy", 2006. Abstract PMID

  8. S. Weinert, N. Bergmann, X. Luo, B. Erdmann and M. Gotthardt. "M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere", 2006. Abstract DOI PMID

  9. D. Wild, M. Béhé, A. Wicki, D. Storch, B. Waser, M. Gotthardt, B. Keil, G. Christofori, J. Reubi and H. Mäcke. "[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting", 2006. Abstract PMID


2005

Papers in international journals

  1. O. Andersen, J. Reiche, V. Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K. Bales, R. Cappai, C. Masters, J. Gliemann, E. Mufson, B. Hyman, S. Paul, A. Nykjaer and T. Willnow. "Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein", 2005. Abstract DOI PMID

  2. M. Béhé, G. Kluge, W. Becker, M. Gotthardt and T. Behr. "Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys", 2005. Abstract PMID

  3. S. Hinterwimmer, M. Gotthardt, R. von Eisenhart-Rothe, S. Sauerland, M. Siebert, T. Vogl, F. Eckstein and H. Graichen. "In vivo contact areas of the knee in patients with patellar subluxation", 2005. Abstract DOI PMID

  4. B. Nock, T. Maina, M. Béhé, A. Nikolopoulou, M. Gotthardt, J. Schmitt, T. Behr and H. Mäcke. "CCK-2/gastrin receptor-targeted tumor imaging with (99m)Tc-labeled minigastrin analogs", 2005. Abstract PMID

  5. J. Peng, K. Raddatz, S. Labeit, H. Granzier and M. Gotthardt. "Muscle atrophy in titin M-line deficient mice", 2005. Abstract DOI PMID


2004

Papers in international journals

  1. P. Boucher and M. Gotthardt. "LRP and PDGF signaling: a pathway to atherosclerosis", 2004. Abstract DOI PMID

  2. M. Gotthardt, A. Battmann, H. Höffken, T. Schurrat, H. Pollum, D. Beuter, S. Gratz, M. Béhé, A. Bauhofer, K. Klose and T. Behr. "18F-FDG PET, somatostatin receptor scintigraphy, and CT in metastatic medullary thyroid carcinoma: a clinical study and an analysis of the literature", 2004. Abstract PMID

  3. M. Gotthardt, O. Boermann, T. Behr, M. Béhé and W. Oyen. "Development and clinical application of peptide-based radiopharmaceuticals", 2004. Abstract PMID

  4. M. Gotthardt, B. Lohmann, T. Behr, A. Bauhofer, C. Franzius, M. Schipper, M. Wagner, H. Höffken, H. Sitter, M. Rothmund, K. Joseph and C. Nies. "Clinical value of parathyroid scintigraphy with technetium-99m methoxyisobutylisonitrile: discrepancies in clinical data and a systematic metaanalysis of the literature", 2004. Abstract DOI PMID

  5. C. Witt, Y. Ono, E. Puschmann, M. McNabb, Y. Wu, M. Gotthardt, S. Witt, M. Haak, D. Labeit, C. Gregorio, H. Sorimachi, H. Granzier and S. Labeit. "Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling", 2004. Abstract PMID


2003

Papers in international journals

  1. M. Béhé, W. Becker, M. Gotthardt, C. Angerstein and T. Behr. "Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives", 2003. Abstract DOI PMID

  2. P. Boucher, M. Gotthardt, W. Li, R. Anderson and J. Herz. "LRP: role in vascular wall integrity and protection from atherosclerosis", 2003. Abstract DOI PMID

  3. M. Gotthardt, M. Béhé, H. Alfke and T. Behr. "Imaging lung tumors with peptide-based radioligands", 2003. Abstract DOI PMID

  4. M. Gotthardt, L. Dirkmorfeld, M. Wied, A. Rinke, M. Béhé, A. Schlieck, H. Höffken, H. Alfke, K. Joseph, K. Klose, T. Behr and R. Arnold. "Influence of somatostatin receptor scintigraphy and CT/MRI on the clinical management of patients with gastrointestinal neuroendocrine tumors: an analysis in 188 patients", 2003. Abstract DOI PMID

  5. M. Gotthardt, R. Hammer, N. Hübner, J. Monti, C. Witt, M. McNabb, J. Richardson, H. Granzier, S. Labeit and J. Herz. "Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure", 2003. Abstract DOI PMID

  6. M. Gotthardt, M. Nowack, M. Béhé, M. Schipper, A. Schlieck, H. Höffken and T. Behr. "Negative correlation between therapeutic success in radioiodine therapy and TcTUs: are TcTUs-adapted dose concepts the only possible answer?", 2003. Abstract DOI PMID

  7. H. Granzier, D. Labeit, Y. Wu, C. Witt, K. Watanabe, S. Lahmers, M. Gotthardt and S. Labeit. "Adaptations in titin's spring elements in normal and cardiomyopathic hearts", 2003. Abstract PMID


2002

Papers in international journals

  1. T. Behr, M. Béhé, G. Kluge, M. Gotthardt, M. Schipper, S. Gratz, R. Arnold, W. Becker and D. Goldenberg. "Nephrotoxicity versus anti-tumour efficacy in radiopeptide therapy: facts and myths about the Scylla and Charybdis", 2002. PMID

  2. T. Behr, M. Gotthardt, W. Becker and M. Béhé. "Radioiodination of monoclonal antibodies, proteins and peptides for diagnosis and therapy. A review of standardized, reliable and safe procedures for clinical grade levels kBq to GBq in the G"ottingen/Marburg experience", 2002. Abstract PMID

  3. P. Boucher, P. Liu, M. Gotthardt, T. Hiesberger, R. Anderson and J. Herz. "Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae", 2002. Abstract DOI PMID

  4. M. Gotthardt, M. Fischer, I. Naeher, J. Holz, H. Jungclas, H. Fritsch, M. Béhé, B. Göke, K. Joseph and T. Behr. "Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results", 2002. Abstract DOI PMID

  5. M. Gotthardt, M. Schipper, C. Franzius, M. Béhé, A. Barth, T. Schurrat, H. Höffken, S. Gratz, K. Joseph and T. Behr. "Follow-up of perfusion defects in pulmonary perfusion scanning after pulmonary embolism: are we too careless?", 2002. Abstract PMID

  6. R. Holtwick, M. Gotthardt, B. Skryabin, M. Steinmetz, R. Potthast, B. Zetsche, R. Hammer, J. Herz and M. Kuhn. "Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure", 2002. Abstract DOI PMID

  7. C. Vasandani, A. Kafrouni, A. Caronna, Y. Bashmakov, M. Gotthardt, J. Horton and D. Spady. "Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice", 2002. Abstract PMID


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