18F-FDG PET/CT in Detecting Metastatic Infection in Children.

I. Kouijzer, G. Blokhuis, J. Draaisma, W. Oyen, L. de Geus-Oei and C. Bleeker-Rovers




Metastatic infection is a severe complication of bacteremia with high morbidity and mortality. The aim of this study was to investigate the diagnostic value of F-FDG PET combined with CT (FDG PET/CT) in children suspected of having metastatic infection.The results of FDG PET/CT scans performed in children because of suspected metastatic infection from September 2003 to June 2013 were analyzed retrospectively. The results were compared with the final clinical diagnosis.FDG PET/CT was performed in 13 children with suspected metastatic infection. Of the total number of FDG PET/CT scans, 38\% were clinically helpful. Positive predictive value of FDG PET/CT was 71\%, and negative predictive value was 100\%.FDG PET/CT appears to be a valuable diagnostic technique in children with suspected metastatic infection. Prospective studies of FDG PET/CT as part of a structured diagnostic protocol are needed to assess the exact additional diagnostic value.

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