Insight into the dynamics, localization and magnitude of antigen-specific immune responses by [(18)F]FLT PET imaging

E. Aarntzen, M. Srinivas, C. Punt, C. Figdor, W. Oyen and I. de Vries

Department of Tumor Immunology; Radboud University Nijmegen Medical Centre (RUNMC); Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre (RUNMC); Nijmegen, The Netherlands.
Aug, 2012

DOI PMID

Abstract

In order for cellular therapeutics to succeed, comprehensive monitoring of the transplanted cells in vivo is required i.e., their localization, functionality and numbers in a longitudinal manner. Recently, dendritic cell based vaccines have been monitored by their effect on lymphocyte activation using [(18)F]FLT PET in cancer patients.