Publications of Gerben Franssen

2018

Papers in international journals

  1. D. Lobeek, G. Franssen, M. Ma, H. Wester, C. Decristoforo, W. Oyen, O. Boerman, S. Terry and M. Rijpkema. "In Vivo Characterization of 4 , javax.xml.bind.JAXBElement@27b763e, Ga-Labeled Multimeric RGD Peptides to Image α, javax.xml.bind.JAXBElement@50cab567, β, javax.xml.bind.JAXBElement@bfd9634, Integrin Expression in 2 Human Tumor Xenograft Mouse Models.", 2018. Abstract DOI PMID


2017

Papers in international journals

  1. L. van der Meer, S. Terry, D. van Ingen Schenau, K. Andree, G. Franssen, D. Roeleveld, B. Metselaar, T. Reinheckel, P. Hoogerbrugge, O. Boerman and F. van Leeuwen. "In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow.", 2017. Abstract/PDF DOI PMID

  2. B. Frigerio, G. Franssen, E. Luison, A. Satta, E. Seregni, M. Colombatti, G. Fracasso, R. Valdagni, D. Mezzanzanica, O. Boerman, S. Canevari and M. Figini. "Full preclinical validation of the 123I-labeled anti-PSMA antibody fragment ScFvD2B for prostate cancer imaging.", 2017. Abstract DOI PMID

  3. L. van der Meer, S. Terry, D. van Ingen Schenau, K. Andree, G. Franssen, D. Roeleveld, J. Metselaar, T. Reinheckel, P. Hoogerbrugge, O. Boerman and F. van Leeuwen. "In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow.", 2017. Abstract DOI PMID


2016

Papers in international journals

  1. L. van Dijk, C. Yim, G. Franssen, J. Kaanders, J. Rajander, O. Solin, T. Gröroos, O. Boerman and J. Bussink. "PET of EGFR with (64) Cu-cetuximab-F(ab')2 in mice with head and neck squamous cell carcinoma xenografts.", 2016. Abstract/PDF DOI PMID

  2. S. Terry, M. Koenders, G. Franssen, T. Nayak, A. Freimoser-Grundschober, C. Klein, W. Oyen, O. Boerman and P. Laverman. "Monitoring Therapy Response of Experimental Arthritis with Radiolabeled Tracers Targeting Fibroblasts, Macrophages, or Integrin ?v?3.", 2016. Abstract/PDF DOI PMID

  3. M. Brom, G. Franssen, L. Joosten, M. Gotthardt and O. Boerman. "The effect of purification of Ga-68-labeled exendin on in vivo distribution.", 2016. Abstract DOI PMID

  4. T. Hutten, S. Thordardottir, H. Fredrix, L. Janssen, R. Woestenenk, J. Tel, B. Joosten, A. Cambi, M. Heemskerk, G. Franssen, O. Boerman, L. Bakker, J. Jansen, N. Schaap, H. Dolstra and W. Hobo. "CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.", 2016. Abstract PMID

  5. K. Chatalic, S. Heskamp, M. Konijnenberg, J. Molkenboer-Kuenen, G. Franssen, M. Clahsen-van Groningen, M. Schottelius, H. Wester, W. van Weerden, O. Boerman and M. de Jong. "Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent.", 2016. Abstract DOI PMID


2015

Papers in international journals

  1. S. Terry, M. Koenders, G. Franssen, T. Nayak, A. Freimoser-Grundschober, C. Klein, W. Oyen, O. Boerman and P. Laverman. "Monitoring therapy response of experimental arthritis with radiolabeled tracers targeting fibroblasts, macrophages or integrin $alpha$v$beta$3.", 2015. Abstract DOI PMID

  2. M. Roerink, R. Groen, G. Franssen, B. Lemmers-van de Weem, O. Boerman and J. van der Meer. "Central delivery of iodine-125-labeled cetuximab, etanercept and anakinra after perispinal injection in rats: possible implications for treating Alzheimer's disease.", 2015. Abstract DOI PMID

  3. T. van der Geest, P. Laverman, D. Gerrits, G. Franssen, J. Metselaar, G. Storm and O. Boerman. "Comparison of three remote radiolabelling methods for long-circulating liposomes.", 2015. DOI PMID

  4. M. Rijpkema, D. Bos, A. Cornelissen, G. Franssen, D. Goldenberg, W. Oyen and O. Boerman. "Optimization of Dual-Labeled Antibodies for Targeted Intraoperative Imaging of Tumors.", 2015.

  5. S. Terry, O. Boerman, D. Gerrits, G. Franssen, J. Metselaar, S. Lehmann, W. Oyen, C. Gerdes and K. Abiraj. "(111)In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages", 2015. Abstract/PDF DOI PMID

  6. J. Oosterwijk-Wakka, M. de Weijert, G. Franssen, W. Leenders, J. van der Laak, O. Boerman, P. Mulders and E. Oosterwijk. "Successful Combination of Sunitinib and Girentuximab in Two Renal Cell Carcinoma Animal Models: A Rationale for Combination Treatment of Patients with Advanced RCC", 2015. Abstract/PDF DOI PMID

  7. L. van Dijk, O. Boerman, G. Franssen, J. Kaanders and J. Bussink. "Cetuximab-F(ab')2-SPECT and FDG-PET for prediction and response monitoring of combined modality treatment of human head and neck carcinomas in a mouse model", 2015. Abstract/PDF DOI PMID

  8. E. Geven, S. Evers, T. Nayak, M. Bergström, F. Su, D. Gerrits, G. Franssen and O. Boerman. "Therapy response monitoring of the early effects of a new BRAF inhibitor on melanoma xenograft in mice: evaluation of (18) F-FDG-PET and (18) F-FLT-PET", 2015. Abstract/PDF DOI PMID

  9. C. van Rij, C. Frielink, D. Goldenberg, R. Sharkey, G. Franssen, S. Lütje, W. McBride, W. Oyen and O. Boerman. "Pretargeted ImmunoPET of Prostate Cancer with an Anti-TROP-2 x Anti-HSG Bispecific Antibody in Mice with PC3 Xenografts", 2015. Abstract/PDF DOI PMID

  10. S. Lütje, C. van Rij, G. Franssen, G. Fracasso, W. Helfrich, A. Eek, W. Oyen, M. Colombatti and O. Boerman. "Targeting human prostate cancer with (111) In-labeled D2B IgG, F(ab')2 and Fab fragments in nude mice with PSMA-expressing xenografts", 2015. Abstract/PDF DOI PMID


2014

Papers in international journals

  1. K. Chatalic, G. Franssen, W. van Weerden, W. McBride, P. Laverman, E. de Blois, B. Hajjaj, L. Brunel, D. Goldenberg, J. Fehrentz, J. Martinez, O. Boerman and M. de Jong. "Preclinical Comparison of Al18F- and 68Ga-Labeled Gastrin-Releasing Peptide Receptor Antagonists for PET Imaging of Prostate Cancer", 2014. Abstract/PDF DOI PMID

  2. S. Terry, K. Abiraj, J. Lok, D. Gerrits, G. Franssen, W. Oyen and O. Boerman. "Can 111In-RGD2 Monitor Response to Therapy in Head and Neck Tumor Xenografts?", 2014. Abstract/PDF DOI PMID

  3. L. van Dijk, O. Boerman, G. Franssen, J. Lok, J. Kaanders and J. Bussink. "Early Response Monitoring with 18F-FDG PET and Cetuximab-F(ab')2-SPECT After Radiotherapy of Human Head and Neck Squamous Cell Carcinomas in a Mouse Model", 2014. Abstract/PDF DOI PMID

  4. S. Lütje, M. Rijpkema, D. Goldenberg, C. van Rij, R. Sharkey, W. McBride, G. Franssen, C. Frielink, W. Helfrich, W. Oyen and O. Boerman. "Pretargeted Dual-Modality Immuno-SPECT and Near-Infrared Fluorescence Imaging for Image-Guided Surgery of Prostate Cancer", 2014. Abstract/PDF DOI PMID

  5. E. Fleuren, Y. Versleijen-Jonkers, M. Roeffen, G. Franssen, U. Flucke, P. Houghton, W. Oyen, O. Boerman and W. van der Graaf. "Temsirolimus combined with cisplatin or bevacizumab is active in osteosarcoma models", 2014. Abstract/PDF DOI PMID

  6. S. Lütje, M. Rijpkema, G. Franssen, G. Fracasso, W. Helfrich, A. Eek, W. Oyen, M. Colombatti and O. Boerman. "Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody", 2014. Abstract/PDF DOI PMID

  7. C. Muselaers, A. Stillebroer, M. Rijpkema, G. Franssen, E. Oosterwijk, P. Mulders, W. Oyen and O. Boerman. "Optical Imaging of Renal Cell Carcinoma with Anti-Carbonic Anhydrase IX Monoclonal Antibody Girentuximab", 2014. Abstract/PDF DOI PMID

  8. M. Ventura, O. Boerman, G. Franssen, E. Bronkhorst, J. Jansen and X. Walboomers. "Monitoring the biological effect of BMP-2 release on bone healing by PET/CT", 2014. Abstract/PDF DOI PMID

  9. M. Rijpkema, W. Oyen, D. Bos, G. Franssen, D. Goldenberg and O. Boerman. "SPECT- and Fluorescence Image-Guided Surgery Using a Dual-Labeled Carcinoembryonic Antigen-Targeting Antibody", 2014. Abstract/PDF DOI PMID

  10. S. Lütje, G. Franssen, R. Sharkey, P. Laverman, E. Rossi, D. Goldenberg, W. Oyen, O. Boerman and W. McBride. "Anti-CEA Antibody Fragments Labeled with [(18)F]AlF for PET Imaging of CEA-Expressing Tumors", 2014. Abstract/PDF DOI PMID

  11. M. Ventura, G. Franssen, E. Oosterwijk, O. Boerman, J. Jansen and X. Walboomers. "SPECT vs. PET monitoring of bone defect healing and biomaterial performance in vivo", 2014. Abstract DOI PMID


2013

Papers in international journals

  1. J. Cany, A. van der Waart, M. Tordoir, G. Franssen, B. Hangalapura, J. de Vries, O. Boerman, N. Schaap, R. van der Voort, J. Spanholtz and H. Dolstra. "Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice", 2013. Abstract/PDF DOI PMID

  2. L. van Dijk, B. Hoeben, H. Stegeman, J. Kaanders, G. Franssen, O. Boerman and J. Bussink. "111In-cetuximab-F(ab')2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts", 2013. Abstract/PDF DOI PMID

  3. I. Dijkgraaf, S. Terry, W. McBride, D. Goldenberg, P. Laverman, G. Franssen, W. Oyen and O. Boerman. "Imaging integrin alpha-v-beta-3 expression in tumors with an 18F-labeled dimeric RGD peptide", 2013. Abstract DOI PMID

  4. C. van Rij, S. Lütje, C. Frielink, R. Sharkey, D. Goldenberg, G. Franssen, W. McBride, E. Rossi, W. Oyen and O. Boerman. "Pretargeted immuno-PET and radioimmunotherapy of prostate cancer with an anti-TROP-2 x anti-HSG bispecific antibody", 2013. Abstract/PDF DOI PMID

  5. R. Schoffelen, O. Boerman, D. Goldenberg, R. Sharkey, C. van Herpen, G. Franssen, W. McBride, C. Chang, E. Rossi, W. van der Graaf and W. Oyen. "Development of an imaging-guided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results", 2013. Abstract/PDF DOI PMID

  6. A. Stillebroer, G. Franssen, P. Mulders, W. Oyen, G. van Dongen, P. Laverman, E. Oosterwijk and O. Boerman. "ImmunoPET imaging of renal cell carcinoma with (124)I- and (89)Zr-labeled anti-CAIX monoclonal antibody cG250 in mice", 2013. Abstract DOI PMID

  7. L. van Dijk, B. Hoeben, J. Kaanders, G. Franssen, O. Boerman and J. Bussink. "Imaging of epidermal growth factor receptor expression in head and neck cancer with SPECT/CT and 111In-labeled cetuximab-F(ab')2", 2013. Abstract DOI PMID


2012

Papers in international journals

  1. R. Schoffelen, W. van der Graaf, R. Sharkey, G. Franssen, W. McBride, C. Chang, D. Bos, D. Goldenberg, W. Oyen and O. Boerman. "Quantitative immuno-SPECT monitoring of pretargeted radioimmunotherapy with a bispecific antibody in an intraperitoneal nude mouse model of human colon cancer", 2012. Abstract DOI PMID

  2. I. Dijkgraaf, G. Franssen, W. McBride, C. D'Souza, P. Laverman, C. Smith, D. Goldenberg, W. Oyen and O. Boerman. "PET of tumors expressing gastrin-releasing peptide receptor with an 18F-labeled bombesin analog", 2012. Abstract/PDF DOI PMID

  3. R. Schoffelen, W. van der Graaf, R. Sharkey, G. Franssen, W. McBride, C. Chang, P. Laverman, D. Goldenberg, W. Oyen, O. Boerman, R. Schoffelen, W. van der Graaf, R. Sharkey, G. Franssen, W. McBride, C. Chang, D. Bos, D. Goldenberg, W. Oyen and O. Boerman. "Pretargeted immuno-PET of CEA-expressing intraperitoneal human colonic tumor xenografts: a new sensitive detection method", 2012. Abstract DOI PMID


2011

Papers in international journals

  1. I. Dijkgraaf, C. Yim, G. Franssen, R. Schuit, G. Luurtsema, S. Liu, W. Oyen and O. Boerman. "PET imaging of $alpha$v$beta$₃ integrin expression in tumours with �?��?�Ga-labelled mono-, di- and tetrameric RGD peptides", 2011. Abstract DOI PMID

  2. G. de Jong, T. Hendriks, G. Franssen, W. Oyen, O. Boerman and R. Bleichrodt. "Adjuvant radioimmunotherapy after radiofrequency ablation of colorectal liver metastases in an experimental model", 2011. Abstract/PDF DOI PMID

  3. C. van Rij, R. Sharkey, D. Goldenberg, C. Frielink, J. Molkenboer, G. Franssen, W. van Weerden, W. Oyen and O. Boerman. "Imaging of prostate cancer with immuno-PET and immuno-SPECT using a radiolabeled anti-EGP-1 monoclonal antibody", 2011. Abstract/PDF DOI PMID


2010

Papers in international journals

  1. S. Heskamp, H. van Laarhoven, J. Molkenboer-Kuenen, G. Franssen, Y. Versleijen-Jonkers, W. Oyen, W. van der Graaf and O. Boerman. "ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model", 2010. Abstract/PDF DOI PMID

  2. B. Hoeben, J. Kaanders, G. Franssen, E. Troost, P. Rijken, E. Oosterwijk, G. van Dongen, W. Oyen, O. Boerman and J. Bussink. "PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors", 2010. Abstract/PDF DOI PMID

  3. R. Schoffelen, W. van der Graaf, G. Franssen, R. Sharkey, D. Goldenberg, W. McBride, E. Rossi, A. Eek, W. Oyen and O. Boerman. "Pretargeted 177Lu radioimmunotherapy of carcinoembryonic antigen-expressing human colonic tumors in mice", 2010. Abstract/PDF DOI PMID

  4. R. Schoffelen, R. Sharkey, D. Goldenberg, G. Franssen, W. McBride, E. Rossi, C. Chang, P. Laverman, J. Disselhorst, A. Eek, W. van der Graaf, W. Oyen and O. Boerman. "Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts", 2010. Abstract DOI PMID


2009

Papers in international journals

  1. T. Stollman, M. Scheer, G. Franssen, K. Verrijp, W. Oyen, T. Ruers, W. Leenders and O. Boerman. "Tumor accumulation of radiolabeled bevacizumab due to targeting of cell- and matrix-associated VEGF-A isoforms", 2009. Abstract/PDF DOI PMID


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